ZincBind—the database of zinc binding sites
نویسندگان
چکیده
منابع مشابه
Competition of zinc, cadmium and calcium for binding sites in sperm of trout and carp
Heavy metal pollutions of aquatic ecosystems have already raised many concerns on aquaticorganisms’health and survival especially on their sperm. The effects of a single metal on sperm may be totallydifferent from cocktail of several metals because of their interactions, so the effects of zinc, cadmium andcalcium on the trout and carp sperms and their competition have been examined by incubatio...
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microRNAs (miRNAs) are an abundant class of small endogenous non-coding RNAs (ncRNAs) of ∼22 nucleotides (nts) in length. These small regulatory molecules are involved in diverse developmental, physiological and pathological processes. miRNAs target mRNAs (mRNAs) for translational repression and/or mRNA degradation. Predictions of miRNA binding sites facilitate experimental validation of miRNA ...
متن کاملThe roles of the two zinc binding sites in DnaJ.
All type I DnaJ (Hsp40) homologues share the presence of two highly conserved zinc centers. To elucidate their function, we constructed DnaJ mutants that separately replaced cysteines of either zinc center I or zinc center II with serine residues. We found that in the absence of zinc center I, the autonomous, DnaK-independent chaperone activity of DnaJ is dramatically reduced. Surprisingly, thi...
متن کاملPrediction of zinc-binding sites in proteins from sequence
MOTIVATION Motivated by the abundance, importance and unique functionality of zinc, both biologically and physiologically, we have developed an improved method for the prediction of zinc-binding sites in proteins from their amino acid sequences. RESULTS By combining support vector machine (SVM) and homology-based predictions, our method predicts zinc-binding Cys, His, Asp and Glu with 75% pre...
متن کاملTHE CALCIUM BINDING SITES OF THE BAKERS' YEAST TRANSKETOLASE
The calcium binding sites of Bakers' Yeast Transketolase (TK) was elucidated by estimating the pKa values of the functional groups that bind to calcium. These pKa's were found to be 6.25 and 7.2 relating to the pKa's of the two immidazol moieties of histidine residues on the enzyme. The rate of the binding of calcium to the enzyme was obtained separately as a function of pH. Maximum values ...
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ژورنال
عنوان ژورنال: Database
سال: 2019
ISSN: 1758-0463
DOI: 10.1093/database/baz006